Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens

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Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens.

The maturation of antigen-presenting dendritic cells (DCs) serves as an important determinant for the regulation of immunity, and overall immune response. We hypothesized that a reduced immune response to donor alloantigens and improved allograft survival could be induced by pre-treating recipients with bone-marrow-derived donor-strain fixed immature DCs (FIDCs). Donor-strain-derived mature and...

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ژورنال

عنوان ژورنال: Immunology

سال: 2009

ISSN: 0019-2805

DOI: 10.1111/j.1365-2567.2009.03158.x